The overarching objective of this project is to develop the lower female reproductive tract within an organ-on-a-chip system. This will create an in-vitro micro vaginal tissue that can mimic the in-vivo organ. The tissue will incorporate structures seen in the vaginal wall, including a stratified squamous epithelium with microvilli, tight junctions, micro folds and mucus.
Bacterial vaginosis (BV) is the most common vaginal infection in women of reproductive age. It has been shown to affect up to 50% of the female population in the developing world and up to 33% of women in the developed world. At present there is no curative treatment and recurrent infection is the norm. It is thought to contribute to miscarriage, premature delivery of babies and pelvic inflammatory disease. It increases the transmission of sexually transmitted infections, including the human immunodeficiency virus (HIV), by two times. It is a disease that is poorly understood and no new therapeutics have been developed in the past 20 years that have shown any alteration in cure rates of BV.
Current work has shown preliminary results using the Vk2/E6E7 cell line grown on electrospun membranes. Additive manufacturing and soft lithography have been used to produce multilayer microfluidic devices.
Meet the Principal Investigator(s) for the project
Dr Ruth Mackay - Dr. Mackay, a Mechanical Engineer, has a keen interest in the biomedical field. She earned her undergraduate degree in Mechanical Engineering from the University of Dundee in 2007. Following that, she pursued her PhD in Micro-electromechanical Systems in 2011, also at the University of Dundee, with funding from a CASE grant provided by the EPSRC in collaboration with IDB Technologies. In 2011, she joined Brunel as a Research Fellow, contributing to a translational MRC grant focused on developing point-of-care devices. Subsequently, in 2015, she assumed the role of a Lecturer at Brunel.
Her research centers around organ-on-a-chip technologies, low-cost point-of-care diagnostic devices, and prosthetics. She currently leads the Organ on a Chip Group at Brunel. Additionally, she lectures in the fields of Finite Element Analysis and Medical Device Engineering.
Related Research Group(s)
Organ-on-a-Chip - The group’s main research focus is on women’s health and developing four main organ-on-a-chip (OOC) models: the breast, vagina, ovary, and placenta.
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Project last modified 21/11/2023