Dr Ahmet Ucar
Senior Lecturer In Toxicology
Heinz Wolff 123a
- Email: ahmet.ucar@brunel.ac.uk
- Tel: +44 (0)1895 266461
Summary
I am a senior lecturer in toxicology at the Brunel University London and an honorary research fellow at the University of Manchester and Manchester Breast Centre. My research vision is to provide a better understanding of the biology of breast cancer stem cells (BCSCs) with the aim of translating this knowledge into novel BCSC-targeting preventive and curative treatments. To this end, we use animal and cell models to study mammary gland development as well as initiation and progression of breast tumorigenesis.
Qualifications:
PhD in Developmental biology (Dr. rer. nat, 2007), University of Goettingen, Germany
MSc in Molecular Biology and Genetics (MSc., 2001), Bilkent University, Turkey
BSc in Molecular Biology and Genetics (BSc., 1999), Bilkent University, Turkey
Professional History:
Senior Lecturer at Brunel University, London, UK (2024- current)
Intermediate Research Fellow, University of Manchester, UK (2017-2024)
Postdoctoral Research Associate, Wellcome Trust Centre for Cell-Matrix Research, Manchester, UK (2014-2017)
Senior Postdoctoral Fellow, German Cancer Research Centre (DKFZ), Heidelberg, Germany (2012-2013)
Postdoctoral Fellow, German Cancer Research Centre (DKFZ), Heidelberg, Germany (2010-2012)
Postdoctoral Fellow, Max Planck Institute for Biophysical Chemistry, Goettingen Germany (2010-2012)
Responsibility
I am a Senior Lecturer in Biosciences with Research and Teaching responsibilities.
Newest selected publications
Gurler, SB., Wagstaff, O., Dimitrova, L., Chen, F., Pedley, R., Weston, W., et al. (2023) 'HER2 overexpression initiates breast tumorigenesis non-cell-autonomously by inducing oxidative stress in the tissue microenvironment'. .
Chen, F., Gurler, SB., Novo, D., Selli, C., Alferez, DG., Eroglu, S., et al. (2023) 'RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells'. Oncogene, 42 (9). pp. 679 - 692. ISSN: 0950-9232
Ucar, A., Ucar, O., Klug, P., Matt, S., Brunk, F., Hofmann, TG. and et al. (2014) 'Adult thymus contains foxN1- epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineages'. Immunity, 41 (2). pp. 257 - 269. ISSN: 1074-7613
Ucar, A., Gupta, SK., Fiedler, J., Erikci, E., Kardasinski, M., Batkai, S., et al. (2012) 'The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy'. Nature Communications, 3 (1). pp. 1078. ISSN: 2041-1723
Ucar, A., Vafaizadeh, V., Jarry, H., Fiedler, J., Klemmt, PAB., Thum, T., et al. (2010) 'MiR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development'. Nature Genetics, 42 (12). pp. 1101 - 1108. ISSN: 1061-4036