Professor Joanna Bridger
Professor
Heinz Wolff 107
- Email: joanna.bridger@brunel.ac.uk
- Tel: +44 (0)1895 266272
Summary
Our research concerns how the genome is spatially organised, influenced and manipulated within its environment, the cell nucleus. The group has had a number of major advances and is currently focused on aspects of genome behaviour in replicative senescence, the premature ageing disease Hutchinson-Gilford Progeria Syndrome, host:pathogen interactions and female cancers. We are wish to understand how structures such as the nuclear lamina, nucleoskeleton and nuclear motors influence the functionality of the genome in health and disease.
Our newest interest is in how the genome can be organised and regulated in low gravity situations and space.
Qualifications
HND BTEC Applied Biology 1985
BSc Microbiology and Genetics, UCL 1990
PhD in Zoology, Chromatin Organisation by the Nuclear Lamina. The University Dundee 1994
PGCert in L&T, Brunel University London 2002
MA in Cult Film and TV, Brunel University London, 2010
Responsibility
Director of the Centre for Genome Engineering and Maintenance (cenGEM)
Co-head Brunel Space Travel and Applied Research (B-STAR) Network
Centre for Genome Engineering and Maintenance | Brunel University London
Newest selected publications
Bridger, JM. and Knight, M. (2024) 'Editorial: Gastropoda immunity and host-pathogen interactions'. Frontiers in Immunology, 15. pp. 1 - 2. ISSN: 1664-3224 Open Access Link
Garimberti, E., Federico, C., Ragusa, D., Bruno, F., Saccone, S., Bridger, JM. and et al. (2024) 'Alterations in Genome Organization in Lymphoma Cell Nuclei due to the Presence of the t(14;18) Translocation'. International Journal of Molecular Sciences, 25 (4). pp. 1 - 12. ISSN: 1661-6596 Open Access Link
Perira Torres, R., Samarakone, C., Bridger, J. and de Castro, I. (2024) 'Pushing the envelope - how the genome interacts with the nuclear envelope in health and disease.', in Donev, R. (ed.) ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY: Nuclear Proteins. Amsterdam : Elsevier.Open Access Link
Schirmer, EC. and Bridger, JM. (2023) 'Editorial: Is aberrant genome organization a cause or consequence of specific diseases?'. Frontiers in Cell and Developmental Biology, 11. pp. 1 - 2. ISSN: 2296-634X Open Access Link
Silahtaroglu, A., Bridger, JM. and Lei, EP. (2022) '3D genome organization'. Scientific Reports, 12 (1). pp. 1 - 2. ISSN: 2045-2322 Open Access Link