The 10th Nuclear Envelope and Chromatin Organisation UK meeting will take place at Brunel University London, on October 3rd and 4th 2024.
We welcome the UK nuclear periphery Network working on different aspects of the nuclear lamina, the NPC canonical and non-canonical functions, genomic associations with periphery, functions of peripheral proteins in health and disease etc.
All talks will be selected from abstracts, while there will also be the opportunity to present work as posters and flash talks. We have kept registration fees low (free for students and technicians) to encourage whole labs to attend and at least one member of each lab in the community to present orally.
This meeting is generously supported by the Biochemical Society.
Please send Talk Titles and Abstracts to neco.abstracts@gmail.com by Monday 2nd September 2024.
Registration Fees
Principal Investigators - £30
Post-doctoral Researchers - £20
PhD Students, Master's Students, Technicians - FREE
[Costs include all sessions and catering on site]
Meeting Schedule
Thursday 3rd October
11.0-12.45 Reception and light lunch (Cavendish room)
12.45- 13.30 Welcome by Prof Jo Bridger, Prof Eric Schirmer, Prof Qiuping Zhang. History of NECO, honouring founder Prof Glenn Morris
Session 1 chaired by Prof Eric Schirmer (20min+10min Q&A)
13.30-14.00 Francesco Saverio Tedesco, Francis Crick Institute, “Developing targeted genetic therapies for skeletal muscle laminopathies using advanced human iPS cell-based disease models”
14.00-14.30 Nuria Ferrandiz, University of Salamanca, “Spatiotemporal Regulation of Nuclear Envelope and ER Reassembly During Mitosis: Insights into Organelle Segregation and Genomic Stability”
14.30-15.00 Sylvain Audibert, University of Sussex, “The proteome of the nuclear periphery in the absence and presence of DNA damage”
15.00-15.15 Poster Flash talks (3-5min, no Q&A): Tong Zhu, Thomas Hale, Rita Pereira, Emily Roberts
15.15-15.45 Coffee break and Posters in Cavendish Room
Session 2 chaired by Prof Tobi Zech (20min+10min Q&A)
15.45-16.15 Paola Vagnarelli, Brunel University London, “Repo-Man /PP1 is one of the major phosphatases responsible for Lamin A de-phosphorylation after mitosis”
16.15-16.45 Alex Ward, University College London, “3D chromatin conformation dynamic changes at the interface between development and cellular response to stimuli”
16.45-17.15 Julia Madsen-Østerbye, University of Oslo, “Chromatin spatial topology at the nuclear lamina is compatible with gene expression during adipose differentiation”
17.15-18.00 Poster Flash talks (3-5min, no Q&A), Emad Shaqoura, Holly Davison, George Doherty, Diana Rubio-Contreras, Oliver Knowles, Negar Nahali, Darren Wilson, Matthew O’Neill
18.00 onwards, meal at the Red Lion: https://www.redlionhotelhillingdon.co.uk/
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Friday 4th October
9.00-9.25 Reception
Session 3 chaired by Prof Paola Vagnarelli (20min+10min Q&A)
9.25-9.30 Abcam sponsor’s talk
9.30-10.00 Qiuping Zhang, King’s College London, “Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere”
10.00-10.30 Adam Byron, University of Manchester, “Adhesion protein control of nuclear membrane signalling and chromatin organisation”
10.30-11.00 Derek Warren, University of East Anglia, “N-acetyltransferase 10 (NAT10) control of nuclear architecture: A novel regulator of smooth muscle cell matrix rigidity response?”
11.00-11.30 Coffee break and Posters in Cavendish Room
Session 4 chaired by Prof Jo Bridger (20min+10min Q&A)
11.30-12.00 Vanja Pekovic-Vaughan, University of Liverpool, “LMNA at the interface with circadian clockwork: implications for skeletal muscle homeostasis and therapeutic interventions”
12.00-12.30 Alia dos Santos, University of Cambridge, “In situ architecture of human sperm nuclear pore complexes”
12.30-13.00 Ines Castro, Brunel University London, “Non-canonical functions of NPCs: sites of splicing”
13.00-14.00 Lunch break and Posters in Cavendish Room
Session 5 Shorter talks chaired by Dr Joseph Hetmanski (12min+3min Q&A)
14.00-14.15 Kumiko Samejima, University of Edinburgh, “Altered prophase chromosome condensation in LaminB1 and B2 depleted cells”
14.15-14.30 Emily Goodall, University of Liverpool, “The role of Rnd3 in nuclear force feedback as a regulator of actomyosin tension”
14.30-14.45 Ioana Olan, University of Cambridge, “Deriving principles of chromatin organisation across cellular senescence, cancer, and differentiation”
14.45-15.00 Jirapath Thammaphet, King’s College London, “Using single-cell RNA sequencing to define mechanisms of vascular ageing and calcification”
15.00-15.15 Ji Qingpin, University of Edinburgh, “Do nuclear envelope invagination networks direct calcium flux to modulate gene expression?”
15.15- 15.30 Haoqun Zhan, University of Cambridge, “LBR safeguards nuclear lamina integrity and cell cycle progression in the absence of A-type lamins”
15.30-15.45 Prizes (sponsored by Abcam/Company of Biologists) and closing remarks from Jo Bridger, Ines Castro and Joseph Hetmanski
Accommodation
Accommodation is not included, however there are many reasonably priced hotel options nearby:
- Lancaster Hotel (on Campus)
- Lyttleton Lodge
- The Red Lion
- Watersedge canal cottages
- Premier Inn, Uxbridge town centre
Transport
The meeting will be held on the 1st floor of the Hamilton Centre (Cavendish/Mead rooms), Brunel University London. Click here for a campus map and see below how to get to Brunel.
Brunel is a single campus in Uxbridge, West London, well connected by public transport to London and the rest of the UK. Brunel is just a short drive from the M25, M4 and M40 motorways; very close to Uxbridge underground station (Metropolitan and Piccadilly lines), West Drayton station (Elizabeth Line) and Heathrow Airport
For more information, visit: brunel.ac.uk/about/finding-us
Any queries, please don’t hesitate to get in touch with: joanna.bridger@brunel.ac.uk; ines.castro@brunel.ac.uk; joseph.hetmanski@brunel.ac.uk