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Dr Camilla Cerutti
Lecturer in Inflammation, Ageing and Cancer Biology

Summary

Dr Camilla Cerutti is a Lecturer in Inflammation, Ageing and Cancer Biology at Brunel University London and
visiting researcher at the European Institute of Oncology since 2023.
Her research focuses on Vascular and Cancer cell biology in particular on cell-cell interaction and cancer metastasis.
Camilla graduated in medical Biotechnology (BSc) at the University of Milan Bicocca in Italy. At the same university she completed a MSc in Industrial Biotechnology-Pharmacogenomic- in 2009 with an ERASMUS final project placement of one year at Complutense University in Madrid, Spain. Here, she investigated the anti-tumoral effects of cannabinoids on breast cancer via JunD in vitro and via Akt in vivo (Caffarel et al. 2008 and 2010).
She completed her PhD in neuro-vascular immunology in 2014 at The Open University in Milton Keynes, UK, studying the role of human brain endothelial microRNAs in leukocyte adhesion in neurodegenerative disorder such as multiple sclerosis.
She developed an microfluidic system to model the interaction of human leukocyte with brain endothelial cells under hemodynamic shear forces in vitro (Cerutti et al 2022). She found that human brain endothelial mir-155, mir-126 and mir-126* regulate leukocyte trafficking at the blood-brain barrier in inflammatory conditions (Cerutti et al 2016 and 2017, Wu 2015).
Dr Cerutti joined the Ridley`s Lab at KCL, London, as research associate postdoc, where she investigated the role of RhoGTPases in human breast and prostate cancer cells in the interaction with endothelial cells and during metastasis formation (Cerutti et al 2021;and Cerutti et al 2024).
This CRUK funded project in collaboration with Prof Muschel Lab at the University of Oxford (Lucotti et al 2019) was further developed as senior research associate postdoc at the University of Bristol leading to find that IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF.
In 2018 she won a Global Research Development Fund from KCL to join Peter Searson Nanobiotechnology Lab at the John Hopkins University (Baltimore, USA) to learn the fabrication of 3D perfusable vascular microvessels.
In 2020 Camilla was awarded the iCARE-2 MSCA H2020 fellowship as principal investigator of the project -Single-cell epigenetic and molecular signatures in human breast cancer metastasis formation - reintegration fellowship in the host lab of Professor Pier Giuseppe Pelicci at the European Institute of Oncology.
Currently, Dr Cerutti lab at Brunel University London investigates cancer metastasis mechanisms with 2D and 3D vascular models to study cell-cell interactions by high-content live-cell imaging.

Qualifications

  • PhD NeuroVascular Immunology (The Open University)
  • MSc in Industrial Biotechnology _ Pharmacogenomic (University of Milan-Bicocca UNIMIB)
  • BSc in Biotechnology _ Medical (University of Milan-Bicocca UNIMIB)

Professional experience

  • 2020-2023 Principal Investigator ICARE2 fellowship, Prof PG Pelicci Cancer&aging lab, IEO, Milan, ITALY.          
  • 2018‐2020 Senior Postdoc Prof. A. Ridley Lab, School of CMM, University of Bristol (UoB), UK.  
  • 2018 Visiting Fellow in Prof. Searson`s Lab, NanoBioTechnology Institute, JHU, USA.         
  • 2016‐2017 Visiting Scientist  in Prof. Muschel Lab, University of Oxford, UK.   
  • 2014‐2018 Postdoc Prof. Anne Ridley group, Randall Centre, King’s College London, UK.                             
  • 2014 Postdoctoral Associate Fellow Prof IA Romero, The Open University, Milton Keynes, UK. 
  • 2006-2007  Master Student Guzman&Sanchez Lab, Complutense University. Madrid, Spain.  

Responsibility

Research and teaching responsabilities.

Newest selected publications

Kakogiannos, N., Scalise, AA., Martini, E., Maderna, C., Benvenuto, AF., D’Antonio, M., et al. (2024) 'GPR126 is a specifier of blood-brain barrier formation in the mouse central nervous system'. Journal of Clinical Investigation, 134 (15). pp. 1 - 17. ISSN: 0021-9738 Open Access Link

Journal article

Cerutti, C., Lucotti, S., Menendez, ST., Reymond, N., Garg, R., Romero, IA., et al. (2024) 'IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF'. Cell Reports, 43 (4). pp. 1 - 48. ISSN: 2639-1856 Open Access Link

Journal article

Owens, HA., Thorburn, LE., Walsby, E., Moon, OR., Rizkallah, P., Sherwani, S., et al. (2024) 'Alzheimer's disease-associated P460L variant of EphA1 dysregulates receptor activity and blood-brain barrier function'. Alzheimer's and Dementia, 0 (ahead of print). pp. 1 - 18. ISSN: 1552-5260 Open Access Link

Journal article

Ferrari, E., Monti, E., Cerutti, C., Visone, R., Occhetta, P., Griffith, LG. and et al. (2023) 'A method to generate perfusable physiologic-like vascular channels within a liver-on-chip model'. Biomicrofluidics, 17 (6). pp. 1 - 12. ISSN: 1932-1058 Open Access Link

Journal article

Campanile, M., Bettinelli, L., Cerutti, C. and Spinetti, G. (2023) 'Bone marrow vasculature advanced in vitro models for cancer and cardiovascular research'. Frontiers in Cardiovascular Medicine, 10. pp. 1261849 - 1261849. ISSN: 2297-055X Open Access Link

Journal article
More publications(21)

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