About us

The Centre for Genome Engineering and Maintenance (CenGEM) at Brunel University London brings together a diverse research network focused on molecular, cellular, organismal and computational aspects of genome biology. Our membership spans multiple disciplines, from cell and molecular biology to engineering and data science; and our interests range from fundamental biological principles to translational research, including of cancer, chronic and rare diseases, across the life-span.

CenGEM has extensive expertise in gene expression and regulation, chromosome dynamics, genome engineering, gene therapy, bio-imaging, stem cell biology, 3D and organoid cell culture, organ-on-a-chip, single-cell biology, and the use of nanoparticles. We explore a range of model organisms (e.g. Drosophila, snail, zebrafish, mouse) and state-of-the-art in vitro and in silico systems, to study solid cancers (breast, bowel, liver, ovarian) and leukaemia, chronic diseases associated with ageing, and rare conditions such as Friedrich’s Ataxia, Hutchinson-Gilford Progeria and Bardet-Biedl Syndrome.

CenGEM are investigating treatments and cures for these diseases and syndromes through identifying new treatments, repurposing pharmaceuticals, exploring alternative medicines, employing stem cell and gene therapies and using genome engineering technologies. 

For more information about the Centre for Genome Engineering and Maintenance, please contact:

Dr Joanna Bridger Email: joanna.bridger@brunel.ac.uk Telephone: +44 (0)1895 266272 Location: Heinz Wolff Building 132