Research profile
The overall aim of the Synthetic Biology is to address major environmental, health and societal challenges by engineering biological systems such that they display functions that do not exist in nature, as well as re-designing existing biological systems so that they perform new functions. Our research focuses on three key areas of activity.
- Gene therapy: Some diseases and disorders happen because certain genes work incorrectly or no longer work at all. We are designing therapeutic interventions for human diseases and disorders by developing the technologies to correct defective genes. Our current projects within this area look at vector development for effective gene therapy, assessing and avoiding the risks of gene therapy (genotoxicity) and using the technologies of gene therapy to give new insights into cancer development.
- Microbial bioengineering: The most exploitable and engineerable organisms are bacteria, so we want to harness their capacity and diversity to create white technologies –those which cause no harm. Our research uses integrated genomics strategies to direct bacterial engineering for a number of translational applications. We look at possible ways to create novel bacteria –bacteria that can produce clean proteins, for example, or bacteria that can improve the performance of cement. Using bioengineered microbes, we look at ways to degrade environmental pollutants; generate products using alternatives to petrochemicals; and reuse waste biomaterials from biomass and biodiesel manufacture. There are even investigations within our theme into ways of addressing antibiotic resistance in medically important bacteria. We are exploring other areas, and are open to developing new lines of research that will make the best use of the strain and widely applicable tools for strain assessment and development, especially when they are directed at projects that have sustainability as part of what they seek to achieve.
- Computer sciences, statistics and maths: We are working on data analysis, bioinformatics, and system modelling to inform synthetic system 30 design and efficient laboratory engineering strategies. These outcomes will support our other strands of research.
Find out about the exciting research we do: browse profiles of our experts, discover the research groups and their inspirational research activities you too could be part of. We’ve also made available extensive reading materials published by our academics and PhD students.
Learn more about research in this area.
Browse the work of subject-relevant research groups
Find a supervisor
Our researchers create knowledge and advance understanding, and equip versatile doctoral researchers with the confidence to apply what they have learnt for the benefit of society. Find out more about working with the Supervisory Team.
You are welcome to approach your potential supervisor directly to discuss your research interests. Search for expert supervisors for your chosen field of research.
PhD topics
While we welcome applications from students with a clear direction for their research, we are providing you with some ideas for your chosen field of research:
- A systems approach to plastic waste valorisation, supervised by Kok Siew Ng
- Ageing-related pre-mRNA splicing of LMNA gene, supervised by Evgeny Makarov
- Antimicrobial resistance in marine mammals (seals) from polluted waters, supervised by Gera Troisi and Ashley Houlden
- Budding yeast as a model for sudden cardiac death, supervised by Thomas Hofken
- Central Nervous system Gene therapy to treat obesity Bardet-Biedl Syndrome (BBS). Analysis of the BBS brain development, supervised by Victor Hernandez
- Decision making for stratified medicine life cycle, supervised by Yang Yang
- Decision making for stratified medicine life cycle, supervised by Yang Yang
- Deep Learning for Medical Imaging, supervised by Yongmin Li
- Deep learning-based autonomous diagnosis of gastrointestinal tract cancers, supervised by Md Nazmul Huda
- Developing Sustainable Decarbonised Polygeneration System Concept for the Production of Hydrogen, Chemicals and Energy, supervised by Kok Siew Ng
- Development of a miniature capsule robot for capsule endoscopy, supervised by Md Nazmul Huda
- Development of a novel PCR-based assay to evaluate CAR-T safety using a human-based genotoxicity model, supervised by Michael Themis
- Development of next generation bioreactor models, supervised by Dale McClure
- Differential expression patterns and transport characteristics of aged cells, supervised by Gudrun Stenbeck
- Genetic and non-genetic factors involved in risk of cardiovascular diseases, supervised by Raha Pazoki
- Health data analysis to identify the role of gene and environment in risk of cardiovascular diseases, supervised by Raha Pazoki
- Hypoxia-driven macrophage modulation in cancer and its impact on T cell immunotherapy, supervised by Doreen Lau
- Identification of determinants of sudden cardiac death and arrhythmias using population studies, supervised by Raha Pazoki
- Individual histone modification roles in regulation of transcription and cell decision-making, supervised by Cristina Correia Antunes Pina
- Investigating molecular disease mechanisms and therapy of Friedreich ataxia, supervised by Sara Anjomani Virmouni
- Investigating the function of common genetic variants that increase colorectal cancer risk., supervised by Annabelle Lewis
- Investigating Therapeutic Effect of Different Antioxidants in Friedreich’s Ataxia (FRDA), supervised by Sara Anjomani Virmouni
- Machine learning approaches in health data science for risk prediction of cardiovascular diseases, supervised by Raha Pazoki
- Multi-omics data analysis for critical disease prediction, supervised by Yang Yang
- Nanoparticles in drug delivery, supervised by Gudrun Stenbeck
- Precision control of Nano-fuel production, supervised by Yang Yang
- Repo-Man function in embryogenesis and differentiation, supervised by Paola Vagnarelli
- Role of CDCA/PP1 in Triple Negative Breast Cancer (TNBC), supervised by Paola Vagnarelli
- Study of the ageing-related pre-mRNA splicing of the LMNA gene, supervised by Evgeny Makarov
- Study of the exosomes: RNA composition of exosomes as potential biomarkers for cancer; Exosomes as a delivery vehicle for therapeutic shRNAs, supervised by Evgeny Makarov
- Sustainable Aviation Fuel Production from Biomass and Waste using a Biorefinery Approach, supervised by Kok Siew Ng
- Sustainable production of high-value compounds using cyanobacteria, supervised by Dale McClure
- Sustainable production of Vitamin K1, supervised by Dale McClure
- Sustainable products & processes - help industry ditch the plastic and toxic chemicals!, supervised by Gera Troisi
- Targeting TERT and the MYCN gene network as a novel therapeutic approach for high-risk neuroblastoma, supervised by Arturo Sala
- Telomere length elongation following treatment with chemotherapeutic drugs., supervised by Terry Roberts
- The impact of chromosomal rearrangements on the genome organisation of leukaemia cells., supervised by Sabrina Tosi
- The mutations in TP53 gene from the glioma patients that trigger the aberrant pre-mRNA splicing, supervised by Evgeny Makarov
- The role of PE/PPE proteins in tuberculosis, supervised by Anthony Tsolaki
- The sustainability of hydrogen production for future energy uses, supervised by Colin Axon and Peter Hewitson
Research journey
This course can be studied 3 years full-time or 6 years part-time, starting in January. Or this course can be studied 3 years full-time or 6 years part-time, starting in October. Or this course can be studied 3 years full-time or 6 years part-time, starting in April.
Research support
UK entry requirements
The general University entrance requirement for registration for a research degree is normally a First or Upper Second Class Honours degree (1st or 2:1).
An interview will be required as part of the admissions process and will be conducted by at least two academic staff members remotely via MS Teams, Zoom, or face to face.
Applicants will be required to submit a personal statement and a research statement.
Please contact your proposed supervisor, where possible, to receive feedback and guidance on your research statement before submitting it. Learn how to prepare a research statement here.
EU and International entry requirements
English language requirements
- IELTS: 7 (min 6 in all areas)
- Pearson: 64 (59 in all subscores)
- BrunELT: 68% (58% in all areas)
- TOEFL: 98 overall (min 20)
Fees and funding
2024/5 entry
International
£23,615 full-time
£11,805 part-time
UK
£4,786 full-time
£2,393 part-time