Dr Annabelle Lewis
Senior Lecturer in Biomedical Sciences
Heinz Wolff 130
- Email: annabelle.lewis@brunel.ac.uk
- Tel: +44 (0)1895 266607
Summary
I am a lecturer in biomedical sciences and run a research laboratory. My research interest is cancer genetics and gene regulation, focusing on colorectal cancer. We use cell lines and animal models to study how common variants in the human genome affect the expression of key cancer genes, and increase the risk of an individual developing cancer.
Qualifications
PhD in Developmental Genetics and Imprinting (The Babraham Institute, University of Cambridge)
BA in Natural Sciences (University of Cambridge)
Newest selected publications
Brown, M., Leon, A., Kedzierska, K., Moore, C., Belnoue-Davis, HL., Flach, S., et al. (2023) 'Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis'. EMBO Molecular Medicine, 15 (10). pp. 1 - 18. ISSN: 1757-4676 Open Access Link
Jerin, S., Harvey, AJ. and Lewis, A. (2023) 'Therapeutic Potential of Protein Tyrosine Kinase 6 in Colorectal Cancer'. Cancers, 15 (14). pp. 1 - 17. ISSN: 2072-6694 Open Access Link
Bridger, JM., Torres Pereira, R., Pina, C., Tosi, S. and Lewis, A. (2022) 'Alterations to Genome Organisation in Stem Cells, their Differentiation and Associated Diseases', in Kloc, M. and Kubiak, JZ. (eds.) Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine. Cham, Switzerland : Springer. , 70. pp. 71 - 102. ISBN 10: 3-031-06573-5. ISBN 13: 978-3-031-06572-9. Open Access Link
O’Cathail, SM., Wu, C-H., Thomas, R., Hawkins, MA., Maughan, TS. and Lewis, A. (2021) 'Nrf2 mediates therapeutic resistance to chemoradiation in colorectal cancer through a metabolic switch'. Antioxidants, 10 (9). pp. 1 - 14. ISSN: 2076-3921 Open Access Link
O'Cathail, SM., Wu, C-H., Lewis, A., Holmes, C., Hawkins, MA. and Maughan, T. (2020) 'NRF2 metagene signature is a novel prognostic biomarker in colorectal cancer'. Cancer Genetics, 248-249. pp. 1 - 10. ISSN: 2210-7762 Open Access Link