Dr Annabelle Lewis
Senior Lecturer in Biomedical Sciences
Heinz Wolff 130
- Email: annabelle.lewis@brunel.ac.uk
- Tel: +44 (0)1895 266607
Brown, M., Leon, A., Kedzierska, K., Moore, C., Belnoue-Davis, HL., Flach, S., et al. (2023) 'Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis'. EMBO Molecular Medicine, 15 (10). pp. 1 - 18. ISSN: 1757-4676 Open Access Link
Jerin, S., Harvey, AJ. and Lewis, A. (2023) 'Therapeutic Potential of Protein Tyrosine Kinase 6 in Colorectal Cancer'. Cancers, 15 (14). pp. 1 - 17. ISSN: 2072-6694 Open Access Link
Bridger, JM., Torres Pereira, R., Pina, C., Tosi, S. and Lewis, A. (2022) 'Alterations to Genome Organisation in Stem Cells, their Differentiation and Associated Diseases', in Kloc, M. and Kubiak, JZ. (eds.) Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine. Cham, Switzerland : Springer. , 70. pp. 71 - 102. ISBN 10: 3-031-06573-5. ISBN 13: 978-3-031-06572-9. Open Access Link
O’Cathail, SM., Wu, C-H., Thomas, R., Hawkins, MA., Maughan, TS. and Lewis, A. (2021) 'Nrf2 mediates therapeutic resistance to chemoradiation in colorectal cancer through a metabolic switch'. Antioxidants, 10 (9). pp. 1 - 14. ISSN: 2076-3921 Open Access Link
O'Cathail, SM., Wu, C-H., Lewis, A., Holmes, C., Hawkins, MA. and Maughan, T. (2020) 'NRF2 metagene signature is a novel prognostic biomarker in colorectal cancer'. Cancer Genetics, 248-249. pp. 1 - 10. ISSN: 2210-7762 Open Access Link
Lewis, A., Russell, H., Kedzierska, K., Buchanan, D., Thomas, R., Tham, E., et al. (2020) 'The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability'. Clinical Epigenetics, 12 (1). pp. 1 - 9. ISSN: 1868-7075 Open Access Link
Lewis, A. (2019) 'CRISPR-Cas9 causes chromosomal instability and re-arrangements in cancer cell lines, detectable by cytogenetic methods'. The CRISPR-Journal, 2 (6). pp. 406 - 416. ISSN: 2573-1599 Open Access Link
Thomas, R., Trapani, D., Goodyer-Sait, L., Tomkova, M., Fernandez-Rozadilla, C., Sahnane, N., et al. (2019) 'The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression'. Scientific Reports, 9 (1). pp. 13463. ISSN: 2045-2322 Open Access Link
Irshad, S., Bansal, M., Guarnieri, P., Davis, H., Al Haj Zen, A., Baran, B., et al. (2017) 'Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer'. Journal of Pathology, 242 (2). pp. 178 - 192. ISSN: 0022-3417 Open Access Link
Cheng, THT., Thompson, DJ., O'Mara, TA., Painter, JN., Glubb, DM., Flach, S., et al. (2016) 'Five endometrial cancer risk loci identified through genome-wide association analysis'. Nature Genetics, 48 (6). pp. 667 - 674. ISSN: 1061-4036 Open Access Link
Davis, H., Irshad, S., Bansal, M., Rafferty, H., Boitsova, T., Bardella, C., et al. (2014) 'Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche'. Nature Medicine, 21 (1). pp. 62 - 70. ISSN: 1078-8956
Lewis, A., Freeman-Mills, L., delaCalle-Mustienes, E., Giráldez-Pérez, RM., Davis, H., Jaeger, E., et al. (2014) 'A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding'. Cell Reports, 8 (4). pp. 983 - 990. ISSN: 2211-1247
Lewis, A. and Tomlinson, I. (2012) 'The utility of mouse models in post-GWAS research'. Science, 338 (6112). pp. 1301 - 1302. ISSN: 0036-8075
Tomlinson, IPM., Carvajal-Carmona, LG., Dobbins, SE., Tenesa, A., Jones, AM., Howarth, K., et al. (2011) 'Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer'. PLoS Genetics, 7 (6). pp. e1002105 - e1002105. ISSN: 1553-7390