
Dr Annabelle Lewis
Senior Lecturer in Biomedical Sciences
Heinz Wolff 130
- Email: annabelle.lewis@brunel.ac.uk
- Tel: +44 (0)1895 266607
Brown, M., Leon, A., Kedzierska, K., Moore, C., Belnoue-Davis, HL., Flach, S., et al. (2023) 'Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis'. EMBO Molecular Medicine, 15 (10). pp. 1 - 18. ISSN: 1757-4676
Jerin, S., Harvey, AJ. and Lewis, A. (2023) 'Therapeutic Potential of Protein Tyrosine Kinase 6 in Colorectal Cancer'. Cancers, 15 (14). pp. 1 - 17. ISSN: 2072-6694
Bridger, JM., Torres Pereira, R., Pina, C., Tosi, S. and Lewis, A. (2022) 'Alterations to Genome Organisation in Stem Cells, their Differentiation and Associated Diseases', in Kloc, M. and Kubiak, JZ. (eds.) Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine. Cham, Switzerland : Springer. , 70. pp. 71 - 102. ISBN 10: 3-031-06573-5. ISBN 13: 978-3-031-06572-9.
O’Cathail, SM., Wu, C-H., Thomas, R., Hawkins, MA., Maughan, TS. and Lewis, A. (2021) 'Nrf2 mediates therapeutic resistance to chemoradiation in colorectal cancer through a metabolic switch'. Antioxidants, 10 (9). pp. 1 - 14. ISSN: 2076-3921
O'Cathail, SM., Wu, C-H., Lewis, A., Holmes, C., Hawkins, MA. and Maughan, T. (2020) 'NRF2 metagene signature is a novel prognostic biomarker in colorectal cancer'. Cancer Genetics, 248-249. pp. 1 - 10. ISSN: 2210-7762
Lewis, A., Russell, H., Kedzierska, K., Buchanan, D., Thomas, R., Tham, E., et al. (2020) 'The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability'. Clinical Epigenetics, 12 (1). pp. 1 - 9. ISSN: 1868-7075
Lewis, A. (2019) 'CRISPR-Cas9 causes chromosomal instability and re-arrangements in cancer cell lines, detectable by cytogenetic methods'. The CRISPR-Journal, 2 (6). pp. 406 - 416. ISSN: 2573-1599
Thomas, R., Trapani, D., Goodyer-Sait, L., Tomkova, M., Fernandez-Rozadilla, C., Sahnane, N., et al. (2019) 'The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression'. Scientific Reports, 9 (1). pp. 13463. ISSN: 2045-2322
Irshad, S., Bansal, M., Guarnieri, P., Davis, H., Al Haj Zen, A., Baran, B., et al. (2017) 'Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer'. Journal of Pathology, 242 (2). pp. 178 - 192. ISSN: 0022-3417
Cheng, THT., Thompson, DJ., O'Mara, TA., Painter, JN., Glubb, DM., Flach, S., et al. (2016) 'Five endometrial cancer risk loci identified through genome-wide association analysis'. Nature Genetics, 48 (6). pp. 667 - 674. ISSN: 1061-4036
Davis, H., Irshad, S., Bansal, M., Rafferty, H., Boitsova, T., Bardella, C., et al. (2014) 'Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche'. Nature Medicine, 21 (1). pp. 62 - 70. ISSN: 1078-8956
Lewis, A., Freeman-Mills, L., delaCalle-Mustienes, E., Giráldez-Pérez, RM., Davis, H., Jaeger, E., et al. (2014) 'A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding'. Cell Reports, 8 (4). pp. 983 - 990. ISSN: 2211-1247
Lewis, A. and Tomlinson, I. (2012) 'The utility of mouse models in post-GWAS research'. Science, 338 (6112). pp. 1301 - 1302. ISSN: 0036-8075
Tomlinson, IPM., Carvajal-Carmona, LG., Dobbins, SE., Tenesa, A., Jones, AM., Howarth, K., et al. (2011) 'Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer'. PLoS Genetics, 7 (6). pp. e1002105 - e1002105. ISSN: 1553-7390