Dr Christian Rudolph
Reader

Summary

Cell division is one of the most fundamental processes in biology. Thousands of proteins have to be made successfully to enable accurate duplication of the genetic information, segregate duplicated chromosomes into daughter cells and to complete cell division. Our lab aims to provide important new insights into how the genome can be duplicated with high accuracy, how damage to the genome can be recognised and repaired and what consequences arise if these processes fail. We use a range of advanced molecular cell biology and genetics techniques for traditional as well as new experimental approaches to study DNA replication and chromosome dynamics, conflicts between DNA replication and transcription, CRISPR-Cas systems and their impact on DNA replication and genome stability and how all these systems contribute to shape the overall architecture of bacterial chromosomes.