Dr Ansar Pathan
Lecturer
Heinz Wolff 227
- Email: ansar.pathan@brunel.ac.uk
- Tel: +44 (0)1895 267761
Rowland, R., Pathan, AA., Satti, I., Poulton, ID., Matsumiya, MML., Whittaker, M., et al. (2013) 'Safety and immunogenicity of an FP9-vectored candidate tuberculosis vaccine (FP85A), alone and with candidate vaccine MVA85A in BCG-vaccinated healthy adults: A phase i clinical trial'. Human Vaccines and Immunotherapeutics, 9 (1). pp. 50 - 62. ISSN: 2164-5515
Pathan, AA., Minassian, AM., Sander, CR., Rowland, R., Porter, DW., Poulton, ID., et al. (2012) 'Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults'. Vaccine, 30 (38). pp. 5616 - 5624. ISSN: 0264-410X
Rowland, R., Brittain, N., Poulton, ID., Minassian, AM., Sander, C., Porter, DW., et al. (2012) 'A review of the tolerability of the candidate TB vaccine, MVA85A compared with BCG and Yellow Fever vaccines, and correlation between MVA85A vaccine reactogenicity and cellular immunogenicity'. Trials in Vaccinology, 1. pp. 27 - 35. ISSN: 1879-4378 Open Access Link
Griffiths, KL., Pathan, AA., Minassian, AM., Sander, CR., Beveridge, NER., Hill, AVS., et al. (2011) 'Th1/Th17 Cell Induction and Corresponding Reduction in ATP Consumption following Vaccination with the Novel Mycobacterium tuberculosis Vaccine MVA85A'. PLoS One, 6 (8). pp. e23463 - e23463. ISSN: 1932-6203 Open Access Link
Beveridge, NER., Price, DA., Casazza, JP., Pathan, AA., Sander, CR., Asher, TE., et al. (2011) 'Correction: Immunisation with BCG and recombinant MVA85A induces long‐lasting, polyfunctional Mycobacterium tuberculosis‐specific CD4+ memory T lymphocyte populations'. European Journal of Immunology, 41 (5). pp. 1501 - 1501. ISSN: 0014-2980
Minassian, AM., Rowland, R., Beveridge, NE., Poulton, ID., Satti, I., Harris, S., et al. (2011) 'A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults'. BMJ Open, 1 (2). pp. e000223 - e000223. ISSN: 2044-6055 Open Access Link
Behboudi, S., Alisa, A., Boswell, S., Anastassiou, J., Pathan, AA. and Williams, R. (2010) 'Expansion of anti-AFP Th1 and Tc1 responses in hepatocellular carcinoma occur in different stages of disease.'. British Journal of Cancer, 102 (4). pp. 748 - 753. ISSN: 0007-0920 Open Access Link
Lalvani, A. and Pathan, AA. (2010) 'Tuberculosis Diagnostic Test'. Available at: http://www.implu.com/patent_applicant/1244135.
De Cassan, SC., Pathan, AA., Sander, CR., Minassian, A., Rowland, R., Hill, AVS., et al. (2010) 'Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A'. Clinical and Vaccine Immunology, 17 (7). pp. 1066 - 1073. ISSN: 1556-6811
Todryk, SM., Pathan, AA., Keating, S., Porter, DW., Berthoud, T., Thompson, F., et al. (2009) 'The relationship between human effector and memory T cells measured by ex vivo and cultured ELISPOT following recent and distal priming'. Immunology, 128 (1). pp. 83 - 91. ISSN: 0019-2805
Sander, CR., Pathan, AA., Beveridge, NE., Poulton, I., Minassian, A., Alder, N., et al. (2009) 'Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in mycobacterium tuberculosis-infected individuals'. American Journal of Respiratory and Critical Care Medicine, 179 (8). pp. 724 - 733. ISSN: 1073-449X Open Access Link
Whelan, KT., Pathan, AA., Sander, CR., Fletcher, HA., Poulton, I., Alder, NC., et al. (2009) 'Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A.'. PLoS One, 4 (6). pp. e5934 - e5934. ISSN: 1932-6203 Open Access Link
Smith, SG., Joosten, SA., Verscheure, V., Pathan, AA., McShane, H., Ottenhoff, TH., et al. (2009) 'Identification of major factors influencing ELISpot-based monitoring of cellular responses to antigens from Mycobacterium tuberculosis.'. PLoS One, 4 (11). pp. e7972 - e7972. ISSN: 1932-6203 Open Access Link
Beveridge, NER., Fletcher, HA., Hughes, J., Pathan, AA., Scriba, TJ., Minassian, A., et al. (2008) 'A comparison of IFNγ detection methods used in tuberculosis vaccine trials'. Tuberculosis, 88 (6). pp. 631 - 640. ISSN: 1472-9792
Fletcher, HA., Pathan, AA., Berthoud, TK., Dunachie, SJ., Whelan, KT., Alder, NC., et al. (2008) 'Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-β1'. Vaccine, 26 (41). pp. 5269 - 5275. ISSN: 0264-410X
McShane, H., Pathan, AA., Hill, A. and Gilbert, SC. (2008) 'Compositions for Immunizing Against Mycobacterium'. Available at: http://www.faqs.org/patents/app/20080226678.
Alisa, A., Boswell, S., Pathan, AA., Ayaru, L., Williams, R. and Behboudi, S. (2008) 'Human CD4+ T cells recognize an epitope within α-fetoprotein sequence and develop into TGF-β-producing CD4 + T cells'. Journal of Immunology, 180 (7). pp. 5109 - 5117. ISSN: 0022-1767
Beveridge, NER., Price, DA., Casazza, JP., Pathan, AA., Sander, CR., Asher, TE., et al. (2007) 'Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4 + memory T lymphocyte populations'. European Journal of Immunology, 37 (11). pp. 3089 - 3100. ISSN: 0014-2980
Pathan, AA., Sander, CR., Fletcher, HA., Poulton, I., Alder, NC., Beveridge, NER., et al. (2007) 'Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: Different boosting intervals and implications for efficacy trials'. PLoS ONE, 2 (10). ISSN: 1932-6203 Open Access Link
Ayaru, L., Pereira, SP., Alisa, A., Pathan, AA., Williams, R., Davidson, B., et al. (2007) 'Unmasking of α-fetoprotein-specific CD4+ T cell responses in hepatocellular carcinoma patients undergoing embolization'. Journal of Immunology, 178 (3). pp. 1914 - 1922. ISSN: 0022-1767
Gilbert, SC., Moorthy, VS., Andrews, L., Pathan, AA., McConkey, SJ., Vuola, JM., et al. (2006) 'Synergistic DNA-MVA prime-boost vaccination regimes for malaria and tuberculosis'. Vaccine, 24 (21). pp. 4554 - 4561. ISSN: 0264-410X
Alisa, A., Ives, A., Pathan, AA., Navarrete, CV., Williams, R., Bertoletti, A. and et al. (2005) 'Analysis of CD4+ T-cell responses to a novel α-fetoprotein-derived epitope in hepatocellular carcinoma patients'. Clinical Cancer Research, 11 (18). pp. 6686 - 6694. ISSN: 1078-0432
McShane, H., Pathan, AA., Sander, CR., Goonetilleke, NP., Fletcher, HA. and Hill, AVS. (2005) 'Boosting BCG with MVA85A: The first candidate subunit vaccine for tuberculosis in clinical trials'. Tuberculosis, 85 (1-2 SPEC.ISS.). pp. 47 - 52. ISSN: 1472-9792
McShane, H., Pathan, AA., Sander, CR., Goonetilleke, NP., Fletcher, HA. and Hill, AVS. (2005) 'Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials'. Tuberculosis, 85 (1-2). pp. 47 - 52. ISSN: 1472-9792
Wilkinson, KA., Wilkinson, RJ., Pathan, A., Ewer, K., Prakash, M., Klenerman, P., et al. (2005) 'Ex Vivo Characterization of Early Secretory Antigenic Target 6-Specific T Cells at Sites of Active Disease in Pleural Tuberculosis'. Clinical Infectious Diseases, 40 (1). pp. 184 - 187. ISSN: 1058-4838
Liebeschuetz, S., Bamber, S., Ewer, K., Deeks, J., Pathan, AA. and Lalvani, A. (2004) 'Diagnosis of tuberculosis in South African children with a T-cell-based assay: A prospective cohort study'. Lancet, 364 (9452). pp. 2196 - 2203. ISSN: 0140-6736
McShane, H., Pathan, AA., Sander, CR., Keating, SM., Gilbert, SC., Huygen, K., et al. (2004) 'Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans'. Nature Medicine, 10 (11). pp. 1240 - 1244. ISSN: 1078-8956
Brookes, RH., Pathan, AA., McShane, H., Hensmann, M., Price, DA. and Hill, AVS. (2003) 'CD8+ T cell-mediated suppression of intracellular Mycobacterium tuberculosis growth in activated human macrophages'. European Journal of Immunology, 33 (12). pp. 3293 - 3302. ISSN: 0014-2980
Lalvani, A. and Pathan, AA. (2003) 'Detection of CD8+ T cell responses to M. tuberculosis'. Available at: http://www.patentvest.com/console/reports/docs/grant/07115361.html.
McConkey, SJ., Reece, WHH., Moorthy, VS., Webster, D., Dunachie, S., Butcher, G., et al. (2003) 'Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans'. Nature Medicine, 9 (6). pp. 729 - 735. ISSN: 1078-8956
Chapman, ALN., Munkanta, M., Wilkinson, KA., Pathan, AA., Ewer, K., Ayles, H., et al. (2002) 'Rapid detection of active and latent tuberculosis infection in HIV-positive individuals by enumeration of Mycobacterium tuberculosis-specific T cells'. AIDS, 16 (17). pp. 2285 - 2293. ISSN: 0269-9370
Pathan, AA., Wilkinson, KA., Klenerman, P., McShane, H., Davidson, RN., Pasvol, G., et al. (2001) 'Direct ex vivo analysis of antigen-specific IFN-γ-secreting CD4 T cells in mycobacterium tuberculosis-infected individuals: Associations with clinical disease state and effect of treatment'. Journal of Immunology, 167 (9). pp. 5217 - 5225. ISSN: 0022-1767
Lalvani, A., Pathan, AA., Durkan, H., Wilkinson, KA., Whelan, A., Deeks, JJ., et al. (2001) 'Enhanced contact tracing and spatial tracking of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells'. Lancet, 357 (9273). pp. 2017 - 2021. ISSN: 0140-6736
Lalvani, A., Pathan, AA., McShane, H., Wilkinson, RJ., Latif, M., Conlon, CP., et al. (2001) 'Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells.'. Am J Respir Crit Care Med, 163 (4). pp. 824 - 828. ISSN: 1073-449X
Lalvani, A., Nagvenkar, P., Udwadia, Z., Pathan, AA., Wilkinson, KA., Shastri, JS., et al. (2001) 'Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians'. Journal of Infectious Diseases, 183 (3). pp. 469 - 477. ISSN: 0022-1899
Pathan, AA., Wilkinson, KA., Wilkinson, RJ., Latif, M., McShane, H., Pasvol, G., et al. (2000) 'High frequencies of circulating IFN-γ-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M. tuberculosis-infected subjects without disease'. European Journal of Immunology, 30 (9). pp. 2713 - 2721. ISSN: 0014-2980
Lalvani, A., Moris, P., Voss, G., Pathan, AA., Kester, KE., Brookes, R., et al. (1999) 'Potent induction of focused Th1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine'. Journal of Infectious Diseases, 180 (5). pp. 1656 - 1664. ISSN: 0022-1899
Lalvani, A., Brookes, R., Wilkinson, RJ., Malin, AS., Pathan, AA., Andersen, P., et al. (1998) 'Human cytolytic and interferon γ-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis'. Proceedings of the National Academy of Sciences of the United States of America, 95 (1). pp. 270 - 275. ISSN: 0027-8424
Lalvani, A., Dong, T., Ogg, G., Pathan, AA., Newell, H., Hill, AVS., et al. (1997) 'Optimization of a peptide-based protocol employing IL-7 for in vitro restimulation of human cytotoxic T lymphocyte precursors'. Journal of Immunological Methods, 210 (1). pp. 65 - 77. ISSN: 0022-1759
Pathan, AA., Green, T., Brown, J. and Navarrete, C. (1992) 'Possible role of amino acids on the β pleated sheet of HLA-DR molecule on the binding of a polymorphic Moab MO2P5D7'. European Journal of Immunogenetics, 19 (6). pp. 465. ISSN: 0960-7420
Pathan, AA., Green, T., Brown, J. and Navarrete, C. (1991) 'Production and characterisation of a polymorphic HLA-DR monoclonal antibody by using transfectant L-cells', in Tsuji, K., Aizawa, M. and Sasazuki, T. (eds.) HLA 1991: Proceedings of the Eleventh International Histocompatibility Workshop and Conference. Oxford Science Publications. , 1. pp. 933 - 934. ISBN 10: 0-19-262390-7.