Professor Arturo Sala
Professor
Heinz Wolff 123A
- Email: arturo.sala@brunel.ac.uk
- Tel: +44 (0)1895 265547
Summary
Trained in Biochemistry and Cellular Biology at the University of Rome and the Italian National Institute of Health, I completed a PhD in Biochemistry at the University of Rome “La Sapienza” on the topic of DNA and RNA methylation in relation to muscle cell differentiation. After a short postdoctoral training in the National Institute of Health in Rome, I won an international post-doctoral fellowship from the Italian Association for Cancer Research (AIRC) and moved to the Kimmel Cancer Institute, Thomas Jefferson University Philadelphia. Working in the laboratory of Prof. Bruno Calabretta, I was the first to characterize the transcription factor and oncoprotein B-MYB and establish its relationship with key tumour suppressor genes, such as p53 and retinoblastoma family members. In 2001 I was recruited by the UCL Institute of Child Health as Senior Lecturer and later promoted to Reader. In UCL I continued to pursue the study of oncogenic transcription factors in the context of neuroblastoma, a childhood tumour affecting the peripheral nervous system. I was appointed Professor of Translational Cancer Research and Deputy Director of the Brunel Institute of Cancer Genetics and Pharmacogenomics in September 2011. In 2016 I joined the Synthetic Biology Theme in the Institute of Environment, Health and Societes.
Responsibility
Member of the Research Ethics Committe
Academic Appeal Commitee panel member
Module coordinator
Newest selected publications
Bibbò, S., Capone, E., Lovato, G., Lamolinara, A., Ponziani, S., Iezzi, M., (2024) 'EV20/Omomyc: A novel dual MYC/HER3 targeting immunoconjugate'. Journal of Controlled Release, 374. pp. 171 - 180. ISSN: 0168-3659 Open Access Link
et al.Cicirò, Y., Ragusa, D. and Sala, A. (2024) 'Expression of the checkpoint kinase BUB1 is a predictor of response to cancer therapies'. Scientific Reports, 14 (1). pp. 1 - 15. ISSN: 2045-2322 Open Access Link
Cicirò, Y., Ragusa, D., Tejera Nevado, P., Lattanzio, R., Sala, G., DesRochers, T., (2023) 'The mitotic checkpoint kinase BUB1 is a direct and actionable target of MYB in adenoid cystic carcinoma'. FEBS Letters, 598 (2). pp. 252 - 265. ISSN: 0014-5793 Open Access Link
et al.Tsakaneli, A., Carregari, VC., Morini, M., Eva, A., Cangemi, G., Chayka, O., (2022) 'MYC regulates metabolism through vesicular transfer of glycolytic kinases'. Open Biology, 11 (12). pp. 1 - 15. ISSN: 2046-2441 Open Access Link
et al.Tagalakis, AD., Jayarajan, V., Maeshima, R., Ho, KH., Syed, F., Wu, L-P., (2021) 'Integrin-Targeted, Short Interfering RNA Nanocomplexes for Neuroblastoma Tumor-Specific Delivery Achieve MYCN Silencing with Improved Survival'. Advanced Functional Materials, 31 (37). pp. 1 - 12. ISSN: 1616-301X Open Access Link
et al.