Dr Concetta Bubici
Senior Lecturer
Heinz Wolff 129
- Email: concetta.bubici@brunel.ac.uk
- Tel: +44 (0)1895 266544
Kaci, FN., Lepore, A., Mohammad, A., Almarzouq, A., Craghill, I., Driessen, C., et al. (2024) 'Targeting Fatty Acid Oxidation Pathways to Overcome Proteasome Inhibitor Resistance in Multiple Myeloma'.Josep Carreras Leukaemia Research Institute Symposia. Badalona, Barcelona. 20 - 22 November.
Lepore, A., Kaci, FN., Bubici, C. and Papa, S. (2023) 'An Integrated Methodology to Quantify the Glycolytic Stress in Plasma Cell Myeloma in Response to Cytotoxic Drugs'. Methods in Molecular Biology, 370. pp. 285 - 296. ISSN: 1064-3745 Open Access Link
Kaci, FN., Lepore, A., Papa, S. and Bubici, C. (2023) 'Screening Kinase-Dependent Phosphorylation of Key Metabolic Reprogramming Regulators'. Methods in Molecular Biology, 2675. pp. 205 - 218. ISSN: 1064-3745 Open Access Link
Papa, S. and Bubici, C. (2023) 'Metabolic Reprogramming: Methods and Protocols'. New York, NY, USA: Humana Press. ISSN 10: 1-0716-3247-7 ISSN 13: 978-1-0716-3246-8
Papa, S., Bubici, C. and Syn, W-K. (2021) 'STARD1: a new rising StAR in cholesterol-mediated hepatocarcinogenesis'. Hepatobiliary Surgery and Nutrition, 10 (6). pp. 910 - 912. ISSN: 2304-3881 Open Access Link
Lepore, A., Choy, PM., Lee, NCW., Carella, MA., Favicchio, R., Briones‐Orta, MA., et al. (2021) 'Phosphorylation and stabilization of PIN1 by JNK promote intrahepatic cholangiocarcinoma growth'. Hepatology, 74 (5). pp. 2561 - 2579. ISSN: 0270-9139 Open Access Link
Bubici, C., Lepore, A. and Papa, S. (2019) 'ASKing No More: The Emerging Role of Dual-Specific Phosphatase 12 in the Regulation of Hepatic Lipid Metabolism'. Hepatology, 70 (4). pp. 1091 - 1094. ISSN: 0270-9139 Open Access Link
Bubici, C. and Papa, S. (2019) 'Editorial: The Warburg effect regulation under siege: The intertwined pathways in health and disease'. Frontiers in Cell and Developmental Biology, 7 (May). pp. 1 - 3. ISSN: 2296-634X Open Access Link
Papa, S., Choy, PM. and Bubici, C. (2018) 'The ERK and JNK pathways in the regulation of metabolic reprogramming.'. Oncogene, 38 (13). pp. 2223 - 2240. ISSN: 0950-9232 Open Access Link
Lee, NCW., Carella, MA., Papa, S. and Bubici, C. (2018) 'High expression of glycolytic genes in Cirrhosis correlates with the risk of developing liver cancer'. Frontiers in Cell and Developmental Biology, 6 (OCT). pp. 138. ISSN: 2296-634X Open Access Link
Papa, S. and Bubici, C. (2018) 'Feeding the Hedgehog: A new meaning for JNK signalling in liver regeneration'. Journal of Hepatology, 69 (3). pp. 572 - 574. ISSN: 0168-8278 Open Access Link
Papa, S. and Bubici, C. (2016) 'Linking apoptosis to cancer metabolism: Another missing piece of JuNK.'. Molecular & Cellular Oncology, 3 (2). pp. e1103398 - e1103398. ISSN: 2372-3556 Open Access Link
Iansante, V., Choy, PM., Fung, SW., Liu, Y., Chai, J-G., Dyson, J., et al. (2015) 'PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation'. NATURE COMMUNICATIONS, 6 (1). pp. 7882. ISSN: 2041-1723 Open Access Link
Bubici, C. and Papa, S. (2013) 'JNK signaling in cancer: In need of new, smarter therapeutic targets'. British Journal of Pharmacology, 171 (1). pp. 24 - 37. ISSN: 0007-1188 Open Access Link
Barbarulo, A., Iansante, V., Chaidos, A., Naresh, K., Rahemtulla, A., Franzoso, G., et al. (2013) 'Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma'. Oncogene, 32 (36). pp. 4231 - 4242. ISSN: 0950-9232 Open Access Link
Papa, S., Bubici, C., Zazzeroni, F. and Franzoso, G. (2009) 'Mechanisms of liver disease: Cross-talk between the NF-κB and JNK pathways'. Biological Chemistry, 390 (10). pp. 965 - 976. ISSN: 1431-6730
Mauro, C., Zazzeroni, F., Papa, S., Bubici, C. and Franzoso, G. (2009) 'The NF-kappaB transcription factor pathway as a therapeutic target in cancer: methods for detection of NF-kappaB activity.'. Methods in molecular biology (Clifton, N.J.), 512. pp. 169 - 207. ISSN: 1064-3745
Papa, S., Zazzeroni, F., Fu, Y-X., Bubici, C., Alvarez, K., Dean, K., et al. (2008) 'Gadd45 beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling'. Journal of Clinical Investigation, 118 (5). pp. 1911 - 1923. ISSN: 0021-9738 Open Access Link
Papa, S., Monti, SM., Vitale, RM., Bubici, C., Jayawardena, S., Alvarez, K., et al. (2007) 'Insights into the structural basis of the GADD45β-mediated inactivation of the JNK kinase, MKK7/JNKK2'. Journal of Biological Chemistry, 282 (26). pp. 19029 - 19041. ISSN: 0021-9258
Pham, CG., Bubici, C., Zazzeroni, F., Knabb, JR., Papa, S., Kuntzen, C. and et al. (2007) 'Upregulation of twist-1 by NF-κB blocks cytotoxicity induced by chemotherapeutic drugs'. Molecular and Cellular Biology, 27 (11). pp. 3920 - 3935. ISSN: 0270-7306
Kuntzen, C., Zazzeroni, F., Pham, CG., Papa, S., Bubici, C., Knabb, JR. and et al. (2007) 'A method for isolating prosurvival targets of NF-kappaB/Rel transcription factors.'. Methods in molecular biology (Clifton, N.J.), 399. pp. 99 - 124. ISSN: 1064-3745
Bubici, C., Papa, S., Dean, K. and Franzoso, G. (2006) 'Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: Molecular basis and biological significance'. Oncogene, 25 (51). pp. 6731 - 6748. ISSN: 0950-9232
Yang, H., Bocchetta, M., Kroczynska, B., Elmishad, AG., Chen, Y., Liu, Z., et al. (2006) '87 TNF-α inhibits asbestos induced cytotoxicity via a NF-kB dependent pathway: A possible mechanism for asbestos-induced oncogenesis'. Lung Cancer, 54. pp. S21 - S21. ISSN: 0169-5002
Yang, H., Bocchetta, M., Kroczynska, B., Elmishad, AG., Chen, Y., Liu, Z., et al. (2006) 'TNF-α inhibits asbestos-induced cytotoxicity via a NF-κB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis'. Proceedings of the National Academy of Sciences of the United States of America, 103 (27). pp. 10397 - 10402. ISSN: 0027-8424
Papa, S., Bubici, C., Zazzeroni, F., Pham, CG., Kuntzen, C., Knabb, JR., et al. (2006) 'The NF-κB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease'. Cell Death and Differentiation, 13 (5). pp. 712 - 729. ISSN: 1350-9047
Bubici, C., Papa, S., Pham, CG., Zazzeroni, F. and Franzoso, G. (2004) 'NF-κB and JNK: An Intricate Affair'. Cell Cycle, 3 (12). pp. 1524 - 1529. ISSN: 1538-4101
Pham, CG., Bubici, C., Zazzeroni, F., Papa, S., Jones, J., Alvarez, K., et al. (2004) 'Ferritin heavy chain upregulation by NF-κB inhibits TNFα-induced apoptosis by suppressing reactive oxygen species'. Cell, 119 (4). pp. 529 - 542. ISSN: 0092-8674
Barnhart, BC., Legembre, P., Pietras, E., Bubici, C., Franzoso, G. and Peter, ME. (2004) 'CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells'. EMBO Journal, 23 (15). pp. 3175 - 3185. ISSN: 0261-4189
Papa, S., Zazzeroni, F., Bubici, C., Jayawardena, S., Alvarez, K., Matsuda, S., et al. (2004) 'Gadd45β mediates the NF-κB suppression of JNK signalling by targeting MKK7/JNKK2'. Nature Cell Biology, 6 (2). pp. 146 - 153. ISSN: 1465-7392
Zazzeroni, F., Papa, S., Algeciras-Schimnich, A., Alvarez, K., Melis, T., Bubici, C., et al. (2003) 'Gadd45β mediates the protective effects of CD40 costimulation against Fas-induced apoptosis'. Blood, 102 (9). pp. 3270 - 3279. ISSN: 0006-4971