Dr Cristiano Scotta
Lecturer in Biosciences
Heinz Wolff 129
- Email: cristiano.scotta@brunel.ac.uk
- Tel: +44 (0)1895 265727
Headen, K., Jakaite, V., Mesaric, VA., Scottá, C., Lombardi, G., Nicolaides, KH. and et al. (2024) 'The Role of Regulatory T Cells and Their Therapeutic Potential in Hypertensive Disease of Pregnancy: A Literature Review'. International Journal of Molecular Sciences, 25 (9). pp. 1 - 14. ISSN: 1661-6596 Open Access Link
Dudreuilh, C., Jarvis, P., Beadle, N., Pilecka, I., Shaw, O., Gardner, L., et al. (2023) 'Can regulatory T cells improve outcomes of sensitised patients after HLA-Ab incompatible renal transplantation: study protocol for the Phase IIa GAMECHANgER-1 trial'. BMC Nephrology, 24 (1). pp. 1 - xx. ISSN: 1471-2369 Open Access Link
Stroukov, W., Mastronicola, D., Albany, CJ., Catak, Z., Lombardi, G. and Scottà, C. (2023) 'OMIP-090: A 20-parameter flow cytometry panel for rapid analysis of cell diversity and homing capacity in human conventional and regulatory T cells'. Cytometry Part A, 103 (5). pp. 362 - 367. ISSN: 1552-4922 Open Access Link
Dudreuilh, C., Basu, S., Shaw, O., Burton, H., Mamode, N., Harris, F., et al. (2023) 'Highly sensitised individuals present a distinct Treg signature compared to unsensitised individuals on haemodialysis'. Frontiers in Transplantation, 2. pp. 1165320. ISSN: 2813-2440
Efthymiou, A., Mureanu, N., Pemberton, R., Tai-MacArthur, S., Mastronicola, D., Scottà, C., et al. (2022) 'Isolation and freezing of human peripheral blood mononuclear cells from pregnant patients'. STAR Protocols, 3 (1). pp. 1 - 8. ISSN: 2666-1667 Open Access Link
Green, S., Politis, M., Rallis, KS., Saenz de Villaverde Cortabarria, A., Efthymiou, A., Mureanu, N., et al. (2021) 'Regulatory T Cells in Pregnancy Adverse Outcomes: A Systematic Review and Meta-Analysis'. Frontiers in Immunology, 12. pp. 1 - 13. ISSN: 1664-3224 Open Access Link
Mohseni, YR., Saleem, A., Tung, SL., Dudreuilh, C., Lang, C., Peng, Q., et al. (2021) 'Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive'. European Journal of Immunology, 51 (10). pp. 2522 - 2530. ISSN: 0014-2980 Open Access Link
Romano, M., Sen, M., Scottà, C., Alhabbab, RY., Rico-Armada, A., Lechler, RI., et al. (2021) 'Isolation and expansion of thymus-derived regulatory T cells for use in pediatric heart transplant patients'. European Journal of Immunology, 51 (8). pp. 2086 - 2092. ISSN: 0014-2980 Open Access Link
Dudreuilh, C., Basu, S., Scottà, C., Dorling, A. and Lombardi, G. (2021) 'Potential Application of T-Follicular Regulatory Cell Therapy in Transplantation'. Frontiers in Immunology, 11. pp. 1 - 18. ISSN: 1664-3224 Open Access Link
Giganti, G., Atif, M., Mohseni, Y., Mastronicola, D., Grageda, N., Povoleri, GAM., et al. (2021) 'Treg cell therapy: How cell heterogeneity can make the difference'. European Journal of Immunology, 51 (1). pp. 39 - 55. ISSN: 0014-2980
Jacob, J., Nadkarni, S., Volpe, A., Peng, Q., Tung, SL., Hannen, RF., et al. (2020) 'Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment'. Molecular Therapy Methods and Clinical Development, 20. pp. 324 - 336. ISSN: 2329-0501 Open Access Link
Harden, PN., Game, DS., Sawitzki, B., Van der Net, JB., Hester, J., Bushell, A., et al. (2020) 'Feasibility, long-term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients'. American Journal of Transplantation, 21 (4). pp. 1603 - 1611. ISSN: 1600-6135 Open Access Link
Sawitzki, B., Harden, PN., Reinke, P., Moreau, A., Hutchinson, JA., Game, DS., et al. (2020) 'Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials'. The Lancet, 395 (10237). pp. 1627 - 1639. ISSN: 0140-6736 Open Access Link
Albany, CJ., Trevelin, SC., Giganti, G., Lombardi, G. and Scottà, C. (2019) 'Getting to the Heart of the Matter: The Role of Regulatory T-Cells (Tregs) in Cardiovascular Disease (CVD) and Atherosclerosis'. Frontiers in Immunology, 10. pp. 1 - 11. ISSN: 1664-3224 Open Access Link
Cossarizza, A., Chang, H-D., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., et al. (2019) 'Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)'. European Journal of Immunology, 49 (10). pp. 1457 - 1973. ISSN: 0014-2980 Open Access Link
Goldberg, R., Scotta, C., Cooper, D., Nissim-Eliraz, E., Nir, E., Tasker, S., et al. (2019) 'Correction of Defective T-Regulatory Cells From Patients With Crohn's Disease by Ex Vivo Ligation of Retinoic Acid Receptor-α'. Gastroenterology, 156 (6). pp. 1775 - 1787. ISSN: 0016-5085
Povoleri, GAM., Nova-Lamperti, E., Scottà, C., Fanelli, G., Chen, YC., Becker, PD., et al. (2018) 'Human retinoic acid–regulated CD161 + regulatory T cells support wound repair in intestinal mucosa'. Nature Immunology, 19 (12). pp. 1403 - 1414. ISSN: 1529-2908
Romano, M., Fanelli, G., Tan, N., Nova-Lamperti, E., McGregor, R., Lechler, RI., et al. (2018) 'Expanded regulatory T cells induce alternatively activated monocytes with a reduced capacity to expand T helper-17 cells'. Frontiers in Immunology, 9 (JUL). pp. 1 - 13. ISSN: 1664-3224 Open Access Link
Safinia, N., Grageda, N., Scottá, C., Thirkell, S., Fry, LJ., Vaikunthanathan, T., et al. (2018) 'Cell therapy in organ transplantation: Our experience on the clinical translation of regulatory T cells'. Frontiers in Immunology, 9 (FEB). pp. 1 - 8. ISSN: 1664-3224 Open Access Link
Fraser, H., Safinia, N., Grageda, N., Thirkell, S., Lowe, K., Fry, LJ., et al. (2018) 'A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials'. Molecular Therapy Methods and Clinical Development, 8. pp. 198 - 209. ISSN: 2329-0501 Open Access Link
Cossarizza, A., Chang, HD., Radbruch, A., Akdis, M., Andrä, I., Annunziato, F., et al. (2017) 'Guidelines for the use of flow cytometry and cell sorting in immunological studies'. European Journal of Immunology, 47 (10). pp. 1584 - 1797. ISSN: 0014-2980
Guggino, G., Scottà, C., Lombardi, G., DIeli, F. and Sireci, G. (2017) 'Invariant natural killer T cells treated with rapamycin or transforming growth factor-β acquire a regulatory function and suppress T effector lymphocytes'. Cellular and Molecular Immunology, 14 (4). pp. 392 - 394. ISSN: 1672-7681
Canavan, JB., Scottà, C., Vossenkämper, A., Goldberg, R., Elder, MJ., Shoval, I., et al. (2016) 'Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease'. Gut, 65 (4). pp. 584 - 594. ISSN: 0017-5749
Scottà, C., Fanelli, G., Hoong, SJ., Romano, M., Lamperti, EN., Sukthankar, M., et al. (2016) 'Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells'. Haematologica, 101 (1). pp. 91 - 100. ISSN: 0390-6078
Safinia, N., Scotta, C., Vaikunthanathan, T., Lechler, RI. and Lombardi, G. (2015) 'Regulatory T cells: Serious contenders in the promise for immunological tolerance in transplantation'. Frontiers in Immunology, 6 (AUG). pp. 438. ISSN: 1664-3224
Edozie, FC., Nova-Lamperti, EA., Povoleri, GAM., Scottà, C., John, S., Lombardi, G. and et al. (2014) 'Regulatory T-cell therapy in the induction of transplant tolerance: The issue of subpopulations'. Transplantation, 98 (4). pp. 370 - 379. ISSN: 0041-1337
Povoleri, GAM., Scottá, C., Nova-Lamperti, EA., John, S., Lombardi, G. and Afzali, B. (2013) 'Thymic versus induced regulatory T cells-who regulates the regulators?'. Frontiers in Immunology, 4 (JUN). pp. 169. ISSN: 1664-3224
Scottà, C., Esposito, M., Fazekasova, H., Fanelli, G., Edozie, FC., Ali, N., et al. (2013) 'Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ T regulatory cell subpopulations'. Haematologica, 98 (8). pp. 1291 - 1299. ISSN: 0390-6078
Afzali, B., Mitchell, PJ., Edozie, FC., Povoleri, GAM., Dowson, SE., Demandt, L., et al. (2013) 'CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner'. European Journal of Immunology, 43 (8). pp. 2043 - 2054. ISSN: 0014-2980
Afzali, B., Edozie, FC., Fazekasova, H., Scottà, C., Mitchell, PJ., Canavan, JB., et al. (2013) 'Comparison of regulatory T cells in hemodialysis patients and healthy controls: implications for cell therapy in transplantation.'. Clinical journal of the American Society of Nephrology : CJASN, 8 (8). pp. 1396 - 1405. ISSN: 1555-9041
Canavan, JB., Afzali, B., Scottà, C., Fazekasova, H., Edozie, FC., Macdonald, TT., et al. (2012) 'A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy'. Blood, 119 (8). pp. e57 - e66. ISSN: 0006-4971
Afzali, B., Mitchell, PJ., Scottà, C., Canavan, J., Edozie, FC., Fazekasova, H., et al. (2011) 'Relative resistance of human CD4 + memory T cells to suppression by CD4 +CD25 + regulatory T cells'. American Journal of Transplantation, 11 (8). pp. 1734 - 1742. ISSN: 1600-6135
Lombardi, G., Sagoo, P., Scotta, C., Fazekasova, H., Smyth, L., Tsang, J., et al. (2011) 'Cell therapy to promote transplantation tolerance: A winning strategy?'. Immunotherapy, 3 (4 SUPPL.). pp. 28 - 31. ISSN: 1750-743X
Scottà, C., Soligo, M., Camperio, C. and Piccolella, E. (2008) 'FOXP3 induced by CD28/B7 interaction regulates CD25 and anergic phenotype in human CD4+CD25- T lymphocytes'. Journal of Immunology, 181 (2). pp. 1025 - 1033. ISSN: 0022-1767
Scottà, C., Garbuglia, AR., Ruggeri, L., Spada, E., Laurenti, L., Perrone, MP., et al. (2008) 'Influence of specific CD4+ T cells and antibodies on evolution of hypervariable region 1 during acute HCV infection'. Journal of Hepatology, 48 (2). pp. 216 - 228. ISSN: 0168-8278
Scottà, C., Tuosto, L., Masci, AM., Racioppi, L., Piccolella, E. and Frasca, L. (2005) 'Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis'. Journal of Leukocyte Biology, 78 (2). pp. 372 - 382. ISSN: 0741-5400
Riganò, R., Buttari, B., De Falco, E., Profumo, E., Ortona, E., Margutti, P., et al. (2004) 'Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis'. Parasite Immunology, 26 (1). pp. 45 - 52. ISSN: 0141-9838
Frasca, L., Scottà, C., Del Porto, P., Nicosia, A., Pasquazzi, C., Versace, I., et al. (2003) 'Antibody-selected mimics of hepatitis C virus hypervariable region 1 activate both primary and memory Th lymphocytes'. Hepatology, 38 (3). pp. 653 - 663. ISSN: 0270-9139
Frasca, L., Scottà, C., Lombardi, G. and Piccolella, E. (2003) 'Both maturation and survival of human dendritic cells are impaired in the presence of anergic/suppressor T cells'. Clinical and Developmental Immunology, 10 (1). pp. 61 - 65. ISSN: 1740-2522