Dr Ines Castro
Lecturer in Genomics
Heinz Wolff 126a
- Email: ines.castro@brunel.ac.uk
- Tel: +44 (0)1895 265741
Summary
Ines is a Lecturer in Genomics since 2023. She is passionate about the genome and how genes switch ON/OFF in a timely and spatially regulated manner. She left Portugal in 2007 to study gene expression regulation in yeast (UMC Utrecht, the Netherlands) and flies (Netherlands Cancer Institute, the Netherlands). She did her PhD at Imperial College London investigating the spatial location of chromosomes in Huntington’s Disease (London, UK). During her two postdocs she looked at chromatin regulation during cell cycle (Brunel University London, UK) and HIV-1 infection (Heidelberg University/EMBL Germany). She is particularly interested at the nuclear periphery and how the genome is organised underneath the Nuclear Pore Complex, the gate of HIV-1 into the nuclei.
Qualifications
PhD, Imperial College London
Fellow, Higher Education Academy
Responsibility
Lecturer/Content Expert, Introduction to Medical Sciences 1, Brunel Medical School since 23/24
Laboratory Theme Leader, Student Selected Component, Brunel Medical School since 24/25
House tutor, Brunel Medical School since 23/24
Biosciences division seminars organiser since 23/24
Newest selected publications
Perira Torres, R., Samarakone, C., Bridger, J. and de Castro, I. (2024) 'Pushing the envelope - how the genome interacts with the nuclear envelope in health and disease.', in Donev, R. (ed.) ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY: Nuclear Proteins. Amsterdam : Elsevier.Open Access Link
de Castro, IJ., Lucic, B. and Lusic, M. (2021) 'Viruses in the Nucleus'. Cold Spring Harbor Perspectives in Biology, 13 (8). pp. 1 - 19. ISSN: 1943-0264 Open Access Link
de Castro, IJ., Toner, B., Xie, SQ., Swingland, J., Hodges, A., Tabrizi, SJ., et al. (2021) 'Altered nuclear architecture in blood cells from Huntington’s disease patients'. Neurological Sciences, 43 (1). pp. 379 - 385. ISSN: 1590-1874
de Castro, IJ. and Lusic, M. (2019) 'Navigating through the nucleus with a virus'. Current Opinion in Genetics and Development, 55. pp. 100 - 105. ISSN: 0959-437X
Sales Gil, R., de Castro, IJ., Berihun, J. and Vagnarelli, P. (2018) 'Protein Phosphatases at the Nuclear Envelope'. Biochemical Society Transactions, 46 (1). pp. 173 - 182. ISSN: 0300-5127 Open Access Link