Testing the effects of drugs used in the clinic on the genomic health of cells from children suffering with the premature ageing disease Hutchinson-Gilford Progeria Syndrome
Funder: SparksDuration: December 2012 - November 2014
People
| Name | Telephone | Office | ||
|---|---|---|---|---|
|
Professor Joanna Bridger Professor (Principal investigator)
T: +44 (0)1895 266272
E: joanna.bridger@brunel.ac.uk |
+44 (0)1895 266272 | joanna.bridger@brunel.ac.uk | Heinz Wolff 107 |
Outputs
Bridger, JM., Torres Pereira, R., Pina, C., Tosi, S. and Lewis, A. (2022) 'Alterations to Genome Organisation in Stem Cells, their Differentiation and Associated Diseases', in Kloc, M. and Kubiak, JZ. (eds.) Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine. Cham, Switzerland : Springer. , 70. pp. 71 - 102. ISBN 10: 3-031-06573-5. ISBN 13: 978-3-031-06572-9. Open Access Link
Clements, CS., Bikkul, MU., Ofosu, W., Eskiw, C., Tree, D., Makarov, E., et al. (2019) 'Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways'. Biogerontology, 20 (3). pp. 337 - 358. ISSN: 1389-5729 Open Access Link
Mehmet, B., Faragher, R., Worthington, G., Meinke, P., Kerr, A., Sammy, A., et al. (2018) 'Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson-Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform'. Genes, Chromosomes and Cancer, 58 (6). pp. 341 - 356. ISSN: 1045-2257 Open Access Link
Bikkul, M., Clements, C., Godwin, L., Goldberg, M., Kill, I. and Bridger, JM. (2018) 'Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson–Gilford progeria syndrome fibroblasts'. Biogerontology, 19 (6). pp. 579 - 602. ISSN: 1389-5729 Open Access Link
Bridger, JM., Bikkul, U., Bourne, G., Clements, C., Kill, IR., Makarov, E. and et al. (2016) 'UNDERSTANDING AND TREATMENT OF HUTCHINSON-GILFORD PROGERIA SYNDROME, A MODEL FOR NORMAL AGING'. [Poster]
Clements, CS., Bikkul, U., Ahmed, MH., Foster, HA., Godwin, LS. and Bridger, JM. (2016) 'Visualizing the Spatial Relationship of the Genome with the Nuclear Envelope Using Fluorescence In Situ Hybridization', in Shackleton, S., Collas, P. and Schirmer, EC. (eds.) The Nuclear Envelope. New York, NY, USA : Humana Press. , 1411. pp. 387 - 406. ISBN 10: 1-4939-3530-5. ISBN 13: 978-1-4939-3528-4. Open Access Link
Gillespie, ZE., Mackay, K., Sander, M., Trost, B., Dawicki, W., Wickramarathna, A., et al. (2016) 'Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/ B-mediated cytokine production'. Nucleus, 6 (6). pp. 490 - 506. ISSN: 1949-1034 Open Access Link
Bikkul, MU., Slijepcevic, P., Anderson, R., Faragher, RGA., Kill, IR. and Bridger, JM. (2015) 'Genome Organisation is affected in immortalised control and Hutchinson-Gilford Progeria Cells'.20th International Chromosome Conference (ICC). Univ Kent, Canterbury, ENGLAND. 1 - 4 September. SPRINGER. pp. 392 - 393. ISSN: 0967-3849 Open Access Link
Bridger, JM., Arican-Gotkas, HD., Foster, HA., Godwin, LS., Harvey, A., Kill, IR., et al. (2014) 'The non-random repositioning of whole chromosomes and individual gene loci in interphase nuclei and its relevance in disease, infection, aging, and cancer'. Advances in Experimental Medicine and Biology, 773. pp. 263 - 279. ISSN: 0065-2598 Open Access Link