Professor Paola Vagnarelli
Professor - Cell Biology

Research area(s)

We are interested in studying cell division and in partiular the dynamics and organisation of chromatin duting the transition from mitosis to G1.

Research Interests

Cell division

Chromatin

Epigenetics

Cancer

Project details

The maintenance of genome integrity is extremely important for both the development and the survival of an organism and mitosis (cell division) plays a crucial role in this process.  To date most of the research on mitosis has focussed on understanding the molecular pathways necessary for faithful chromosome segregation in early mitosis but much less in know about the regulation of mitotic exit. My group is interested in understanding the molecular basis of the coordination between chromosome structure/dynamics in mitotic exit and the reformation of a functional G1 nucleus. We are particularly interested in chromatin-associated protein phosphatases and their role in regulating post-mitotic events.

Breast Cancer Campaign:   Role of the Repo-Man/PP1 signalling pathways in breast cancer progression 

BBSRC: Protein Phosphatase 1 (PP1) in the regulation of mitotic exit and nuclear organisation

The Wellcome Trust:    CHROMATIN RE-ORGANISATION AT THE TRANSITION FROM MITOSIS TO G1: HOW PHOSPHO-SWITCHES REGULATE THE PROCESS IN SPACE AND TIME.